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WP5 - Severe Insulin-Resistant Diabetes (SIRD) - mechanisms & pathways

WP leaders
 

Ola Hansson and Eva Degerman

Objectives

  • To identify targetable mechanisms and pathways underlying initiation and progression of SIRD
  • To identify common pathways of insulin resistance in various target organs

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Selected publications

  • Pålbrink AK et al. Inner ear is a target for insulin signaling and insulin resistance: evidence from mice and auditory HEI-OC1 cells. BMJ Open Diabetes Res Care 2020 https://pubmed.ncbi.nlm.nih.gov/32238362/
  • Mohr AA et al. A glucose-stimulated BOLD fMRI study of hypothalamic dysfunction in mice fed a high-fat and high-sucrose diet. J Cereb Blood Flow Metab 2020 https://pubmed.ncbi.nlm.nih.gov/32757742/
  • Degerman E et al. Endolymphatic hydrops induced by different mechanisms responds differentially to spironolactone: a rationale for understanding the diversity of treatment responses in hydropic inner ear disease. Acta Otolaryngol 2019 https://pubmed.ncbi.nlm.nih.gov/31145014/
  • Morén B et al. EHD2 regulates adipocyte function and is enriched at cell surface-associated lipid droplets in primary human adipocytes. Mol Biol Cell 2019 https://pubmed.ncbi.nlm.nih.gov/30811273/
  • Hien TT et al. MicroRNA-dependent regulation of KLF4 by glucose in vascular smooth muscle. J Cell Physiol 2018 https://pubmed.ncbi.nlm.nih.gov/29574754/