WP7 - Moderate Age-related Diabetes (MARD) - mehanisms & pathways

Press releases

• Two ERC Advanced Grants awarded to Lund University researchers, 2020 https://www.lunduniversity.lu.se/article/two-erc-advanced-grants-awarded-lund-university-researchers
• Similarity between high-risk atherosclerotic plaque and cancer cells discovered, 2018 https://www.lunduniversity.lu.se/article/similarity-between-high-risk-atherosclerotic-plaque-and-cancer-cells-discovered

Selected publications

• Fritzen AM et al. ApoA-1 improves glucose tolerance by increasing glucose uptake into heart and skeletal muscle independently of AMPKα2. Mol Metab 2020 https://pubmed.ncbi.nlm.nih.gov/32244181/
• Nilsson O et al. Apolipoprotein A-I primes beta cells to increase glucose stimulated insulin secretion. Biochim Biophys Acta Mol Basis Dis 2020 https://pubmed.ncbi.nlm.nih.gov/31765698/
• Edmunds SJ et al. ApoAI-derived peptide increases glucose tolerance and prevents formation of atherosclerosis in mice. Diabetologia 2019 https://pubmed.ncbi.nlm.nih.gov/31069401/
• Gonçalves I et al. sTRAIL-R2 (Soluble TNF [Tumor Necrosis Factor]-Related Apoptosis-Inducing Ligand Receptor 2) a Marker of Plaque Cell Apoptosis and Cardiovascular Events. Stroke. 2019 https://pubmed.ncbi.nlm.nih.gov/31272321/
• Wigren M et al. Lack of Ability to Present Antigens on Major Histocompatibility Complex Class II Molecules Aggravates Atherosclerosis in ApoE-/- Mice. Circulation 2019 https://pubmed.ncbi.nlm.nih.gov/31136220/
• Domingo-Espín J et al. Site-specific glycations of apolipoprotein A-I lead to differentiated functional effects on lipid-binding and on glucose metabolism. Biochim Biophys Acta Mol Basis Dis 2018 https://pubmed.ncbi.nlm.nih.gov/29802959/
• Tomas L et al. Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques. Eur Heart J. 2018 https://pubmed.ncbi.nlm.nih.gov/29562241/