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WP6 - Mild obesity-related diabetes (MOD) - mechanisms & pathways

WP leaders

Nils Wierup, Cecilia Holm, and Olga Göransson


  • To identify targetable mechanisms and pathways underlying initiation and progression of MOD.




















Press releases

Selected publications

  • Herzog K et al. Metabolic Effects of Gastric Bypass Surgery: Is It All About Calories? Diabetes 2020
  • Lindqvist A et al. Ghrelin suppresses insulin secretion in human islets and type 2 diabetes patients have diminished islet ghrelin cell number and lower plasma ghrelin levels. Mol Cell Endocrinol 2020
  • Negoita F et al. JUP/plakoglobin is regulated by salt-inducible kinase 2, and is required for insulin-induced signalling and glucose uptake in adipocytes. Cell Signal. 2020
  • Axling U et al. Increased whole body energy expenditure and protection against diet-induced obesity in Cyp8b1-deficient mice is accompanied by altered adipose tissue features. Adipocyte. 2020