WP4 - Severe Insulin-Deficient Diabetes (SIDD) - mechanisms & pathways
WP leaders
Lena Eliasson and Enming Zhang (as Erik Renströms deputy)
Objectives
- Identify targetable mechanisms and pathways underlying initiation and progression of SIDD
- Identify disease heterogeneities that influence the insulin secretion process
- Evaluate the therapeutic potential of novel insulinotropic and glucagonostatic agents
Press releases
- New discovery restores insulin cell function in type 2 diabetes (Albert Salehi, Claes Wollheim, 2019): https://www.lunduniversity.lu.se/article/new-discovery-restores-insulin…
- New function of a key component in the immune system discovered (Anna Blom & Erik Renström, 2018): https://www.lunduniversity.lu.se/article/new-function-key-component-imm…
Selected publications
- Esguerra JLS et al. Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA. Mol Metab 2020 https://pubmed.ncbi.nlm.nih.gov/32029226/
- Ye Y et al. The TCF7L2-dependent high-voltage activated calcium channel subunit α2δ-1 controls calcium signaling in rodent pancreatic beta-cells. Mol Cell Endocrinol 2020 https://pubmed.ncbi.nlm.nih.gov/31805307/
- Nagao M et al. Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells. Diabetes 2020 https://pubmed.ncbi.nlm.nih.gov/32198214/
- Eliasson L et al. MicroRNA Networks in Pancreatic Islet Cells: Normal Function and Type 2 Diabetes. Diabetes 2020 (Review) https://pubmed.ncbi.nlm.nih.gov/32312896/
- Wendt A et al. Pancreatic α-cells - The unsung heroes in islet function. Semin Cell Dev Biol 2020 (Review) https://pubmed.ncbi.nlm.nih.gov/31983511/
- Dwivedi OP et al. Loss of ZnT8 function protects against diabetes by enhanced insulin secretion. Nat Genet 2019 https://pubmed.ncbi.nlm.nih.gov/31676859/
- Bijkerk R et al. In Vivo Silencing of MicroRNA-132 Reduces Blood Glucose and Improves Insulin Secretion. Nucleic Acid Ther 2019 https://pubmed.ncbi.nlm.nih.gov/30672723/
- King BC et al. Complement Component C3 Is Highly Expressed in Human Pancreatic Islets and Prevents β Cell Death via ATG16L1 Interaction and Autophagy Regulation. Cell Metab 2019 https://pubmed.ncbi.nlm.nih.gov/30293775/
- Zhang E et al. Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells. Cell Metab 2019 https://pubmed.ncbi.nlm.nih.gov/30293774/
- Edlund A et al. Defective exocytosis and processing of insulin in a cystic fibrosis mouse model. J Endocrinol 2019 https://pubmed.ncbi.nlm.nih.gov/30721137/
News from Follicum (some in Swedish)
- http://follicum.se/follicum-erhaller-vinnova-anslag-for-studier-av-fol-peptiders-bindning-till-receptorer-pa-pankreas-celler/ (31 Jan 2020)
- https://news.cision.com/se/follicum/r/follicum-rapporterar-positiva--humana-ex-vivo-data-fran-prekliniska-diabetesstudier-med-ny-klass-av-,c2992470 (17 Dec 2019)
- https://news.cision.com/se/follicum/r/follicum-erhaller-eurostars-anslag-for-utveckling-av-bolagets-first-in-class-behandling-av-diabetes,c2939865 (24 Oct 2019)
- http://follicum.com/follicum-receives-ludc-post-doc-funding-for-novel-diabetes-peptide-mode-of-action-research/ (13 Jun 2019)
- https://endpts.com/sp/follicum-a-swedish-biotech-company-born-to-find-a-treatment-for-hair-loss-now-has-diabetes-in-its-crosshairs/ (26 Feb 2019)
- http://follicum.com/article-in-biostock-follicum-shows-rapid-progress-with-diabetes-drug-candidate/ (7 Jan 2019)