WP2 - Biomarker discovery in observational prospective studies
WP leaders
Charlotte Ling and Hindrik Mulder
Objectives
- To identify and validate new biomarkers for early onset of disease
- To identify and validate new biomarkers from and applicable to, broad populations in order to predict disease progression (including complications), as well as to explore whether these biomarkers are enriched in some to the new clusters obtained by using a more fine-tuned diabetes classification
- To identify and validate new biomarkers of efficacy response, including dynamic biomarkers that change with interventions (i.e. experimental therapeutic, Standard of Care, life style interventions)
Press releases
- Metformin for type 2 diabetes patients or not? Researchers now have the answer, 2020 https://www.lunduniversity.lu.se/article/metformin-type-2-diabetes-patients-or-not-researchers-now-have-answer
- Strict diet explains metabolic effect of gastric bypass surgery, 2020 https://www.lunduniversity.lu.se/article/strict-diet-explains-metabolic-effect-gastric-bypass-surgery
- The world's largest stem cell biobank launched, 2020 https://www.lunduniversity.lu.se/article/worlds-largest-stem-cell-biobank-launched
- Blood lipid profile predicts risk of type 2 diabetes better than obesity, 2020 https://www.lunduniversity.lu.se/article/blood-lipid-profile-predicts-risk-type-2-diabetes-better-obesity
- How lifestyle affects our genes: review, 2019 https://www.lunduniversity.lu.se/article/how-lifestyle-affects-our-genes-review
- New link between gut bacteria and obesity, 2018 https://www.lunduniversity.lu.se/article/new-link-between-gut-bacteria-and-obesity
Selected publications
- Herzog K et al. Metabolic Effects of Gastric Bypass Surgery: Is It All About Calories? Diabetes 2020 https://pubmed.ncbi.nlm.nih.gov/32527768/
- Eliasson L et al. Micro(RNA) Management and Mismanagement of the Islet. J Mol Biol 2020 (Review) https://pubmed.ncbi.nlm.nih.gov/31628943/
- García-Calzón S et al. Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes. Sci Transl Med 2020 https://pubmed.ncbi.nlm.nih.gov/32938793/
- Ottosson F et al. The gut microbiota-related metabolite phenylacetylglutamine associates with increased risk of incident coronary artery disease. J Hypertens 2020 https://pubmed.ncbi.nlm.nih.gov/32665522/
- Ottosson F et al. Connection Between BMI-Related Plasma Metabolite Profile and Gut Microbiota. J Clin Endocrinol Metab 2018 https://pubmed.ncbi.nlm.nih.gov/29409054/
- Schulz CA et al. Plasma kidney injury molecule-1 (p-KIM-1) levels and deterioration of kidney function over 16 years. Nephrol Dial Transplant 2020 https://pubmed.ncbi.nlm.nih.gov/30629206/
- Fernandez C et al. Plasma Lipidome and Prediction of Type 2 Diabetes in the Population-Based Malmö Diet and Cancer Cohort. Diabetes Care 2020 https://pubmed.ncbi.nlm.nih.gov/31818810/
- Ericson U et al. A Health-Conscious Food Pattern Is Associated with Prediabetes and Gut Microbiota in the Malmö Offspring Study. J Nutr 2019 https://pubmed.ncbi.nlm.nih.gov/31851320/
- Ling C et al. Epigenetics in Human Obesity and Type 2 Diabetes. Cell Metab. 2019 (Review) https://pubmed.ncbi.nlm.nih.gov/30982733/