Menu

Javascript is not activated in your browser. This website needs javascript activated to work properly.
You are here

Jointly Modelling SNPs with Survival & Longitudinal Trait - a statistical seminar applied on Type 2 Diabetes

CRC-seminars
In observational cohorts, longitudinal data are collected with repeated measurements at predetermined time points for many biomarkers, along with other variables measured at baseline. In these cohorts, time until a certain event of interest occurs is reported and very often, a relationship will be observed between some biomarker repeatedly measured over time and that event. Joint models were designed to efficiently estimate statistical parameters describing this relationship by combining a mixed model for the longitudinal biomarker trajectory and a survival model for the time until occurrence of the event, using a set of random effects to account for the relationship between the two types of data. We discuss the implementation of joint models in genetic association studies. First, we check model consistency based on different simulation scenarios, by varying sample sizes, minor allele frequencies and number of repeated measurements. Second, using genotypes assayed with the Metabochip DNA arrays (Illumina) from about 4,500 individuals recruited in the French cohort D.E.S.I.R. (Data from an Epidemiological Study on the Insulin Resistance syndrome), we assess the feasibility of implementing the joint modelling approach in a real high-throughput genomic dataset. An alternative model approximating the joint model, called the Two-Step approach (TS), is also presented. Although the joint model shows more precise and less biased estimators than its alternative counterpart, the TS approach results in much reduced computational times, and could thus be used for testing millions of SNPs at the genome-wide scale.

Speaker: Mickaël Canouil, PhD, CNRS, Université de Lille 2, Institut Pasteur de Lille, Chru, France

Host: Paul Franks

Time: 
21 January 2019 14:00 to 15:00
Location: 
Agardh lecture hall, CRC, Jan Waldenstöms gata 35, SUS Malmö
Contact: 
pernilla.siming [at] med.lu.se

About the event

Time: 
21 January 2019 14:00 to 15:00
Location: 
Agardh lecture hall, CRC, Jan Waldenstöms gata 35, SUS Malmö
Contact: 
pernilla.siming [at] med.lu.se

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00