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Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy.

Author:
  • Elisabet Agardh
  • Annika Lundstig
  • Alexander Perfilyev
  • Petr Volkov
  • Tove Freiburghaus
  • Eero Lindholm
  • Tina Rönn
  • Carl-David Agardh
  • Charlotte Ling
Publishing year: 2015
Language: English
Publication/Series: BMC Medicine
Volume: 13
Issue: 182
Document type: Journal article
Publisher: BioMed Central

Abstract english

Epigenetic variation has been linked to several human diseases. Proliferative diabetic retinopathy (PDR) is a major cause of vision loss in subjects with diabetes. However, studies examining the association between PDR and the genome-wide DNA methylation pattern are lacking. Our aim was to identify epigenetic modifications that associate with and predict PDR in subjects with type 1 diabetes (T1D).

Keywords

  • Endocrinology and Diabetes

Other

Published
  • Ophthalmology, Malmö
  • Diabetes and Celiac Unit
  • Epigenetics and Diabetes
  • Diabetes and Endocrinology
  • ISSN: 1741-7015
Tina Rönn
E-mail: tina.ronn [at] med.lu.se

Assistant researcher

Epigenetics and Diabetes

+46 40 39 12 18

CRC 91-12-021

33

Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00