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Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.

Author:
  • Elin Hall
  • Petr Volkov
  • Tasnim Dayeh
  • Karl Bacos
  • Tina Rönn
  • Marloes Dekker Nitert
  • Charlotte Ling
Publishing year: 2014
Language: English
Publication/Series: BMC Medicine
Volume: 12
Issue: 1
Document type: Journal article
Publisher: BioMed Central

Abstract english

Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated fatty acids has detrimental effects on islet function and insulin secretion. Altered gene expression and epigenetics may contribute to T2D and obesity. However, there is limited information on whether fatty acids alter the genome-wide transcriptome profile in conjunction with DNA methylation patterns in human pancreatic islets. To dissect the molecular mechanisms linking lipotoxicity to impaired insulin secretion, we investigated the effects of a 48 h palmitate treatment in vitro on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.

Keywords

  • Endocrinology and Diabetes

Other

Published
  • Epigenetics and Diabetes
  • ISSN: 1741-7015
Tina Rönn
E-mail: tina.ronn [at] med.lu.se

Assistant researcher

Epigenetics and Diabetes

+46 40 39 12 18

CRC 91-12-021

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Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00