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Nanoparticles as pseudostationary phase in capillary electrochrornatography/ESI-MS

Author:
  • Peter Viberg
  • M Jornten-Karlsson
  • P Petersson
  • Peter Spégel
  • Staffan Nilsson
Publishing year: 2002
Language: English
Pages: 4595-4601
Publication/Series: Analytical Chemistry
Volume: 74
Issue: 18
Document type: Journal article
Publisher: The American Chemical Society

Abstract english

A novel technique that uses polymer nanoparticles as pseudostationary phase in capillary electrochromatography with electrospray ionization mass spectrometry detection is described. A continuous full filling technique in which the nanoparticles were suspended in the entire electrolyte volume as well as a conventional partial filling technique is presented. No nanoparticles entered the mass spectrometer, which was fitted with an orthogonal electrospray interface, despite the continuous flow of nanoparticles into the interface. Nanoparticles (average diameter 160 nm) were prepared from methacrylic acid, methyl methacrylate, and trimethylolpropane trimethacrylate by utilizing a precipitation polymerization technique. Salbutamol, nortriptyline, and diphenhydramine were used as analytes. The interaction between analytes and nanoparticles was found to be predominantly ionic.

Keywords

  • Analytical Chemistry

Other

Published
  • ISSN: 1520-6882
Peter Spegel
E-mail: peter.spegel [at] chem.lu.se

Researcher

Centre for Analysis and Synthesis

1

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