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Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line.

Author:
  • Lotta Andersson
  • Berengere Valtat
  • Annika Bagge
  • Vladimir Sharoyko
  • David Nicholls
  • Philippe Ravassard
  • Raphael Scharfmann
  • Peter Spégel
  • Hindrik Mulder
Publishing year: 2015
Language: English
Publication/Series: PLoS ONE
Volume: 10
Issue: 3
Document type: Journal article
Publisher: Public Library of Science

Abstract english

Studies on beta cell metabolism are often conducted in rodent beta cell lines due to the lack of stable human beta cell lines. Recently, a human cell line, EndoC-βH1, was generated. Here we investigate stimulus-secretion coupling in this cell line, and compare it with that in the rat beta cell line, INS-1 832/13, and human islets.

Keywords

  • Endocrinology and Diabetes

Other

Published
  • Molecular Metabolism
  • Diabetes and Endocrinology
  • ISSN: 1932-6203
Peter Spegel
E-mail: peter.spegel [at] chem.lu.se

Researcher

Centre for Analysis and Synthesis

1

Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00