Lund University is celebrating 350 years. Read more on lunduniversity.lu.se

Menu

Javascript is not activated in your browser. This website needs javascript activated to work properly.

Glycogen metabolism in the glucose-sensing and supply-driven β-cell

Author:
  • Lotta E. Andersson
  • Lisa M. Nicholas
  • Karin Filipsson
  • Jiangming Sun
  • Anya Medina Benavente
  • Mahmoud Al-Majdoub
  • Malin Fex
  • Hindrik Mulder
  • Peter Spégel
Publishing year: 2016-12-01
Language: English
Pages: 4242-4251
Publication/Series: FEBS Letters
Volume: 590
Issue: 23
Document type: Journal article (letter)
Publisher: Wiley-Blackwell

Abstract english

Glycogen metabolism in β-cells may affect downstream metabolic pathways controlling insulin release. We examined glycogen metabolism in human islets and in the rodent-derived INS-1 832/13 β-cells and found them to express the same isoforms of key enzymes required for glycogen metabolism. Our findings indicate that glycogenesis is insulin-independent but influenced by extracellular glucose concentrations. Levels of glycogen synthase decrease with increasing glucose concentrations, paralleling accumulation of glycogen. We did not find cAMP-elicited glycogenolysis and insulin secretion to be causally related. In conclusion, our results reveal regulated glycogen metabolism in human islets and insulin-secreting cells. Whether glycogen metabolism affects insulin secretion under physiological conditions remains to be determined.

Keywords

  • Cell and Molecular Biology
  • human islets
  • INS-1 832/13
  • insulin secretion

Other

Published
  • Molecular Metabolism
  • ISSN: 0014-5793
Peter Spegel
E-mail: peter.spegel [at] chem.lu.se

Researcher

Centre for Analysis and Synthesis

1

Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00