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Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk

Author:
  • Judith S. Brand
  • Yvonne T. van der Schouw
  • N. Charlotte Onland-Moret
  • Stephen J. Sharp
  • Ken K. Ong
  • Kay-Tee Khaw
  • Eva Ardanaz
  • Pilar Amiano
  • Heiner Boeing
  • Maria-Dolores Chirlaque
  • Francoise Clavel-Chapelon
  • Francesca L. Crowe
  • Blandine de Lauzon-Guillain
  • Eric J. Duell
  • Guy Fagherazzi
  • Paul Franks
  • Sara Grioni
  • Leif Groop
  • Rudolf Kaaks
  • Timothy J. Key
  • Peter Nilsson
  • Kim Overvad
  • Domenico Palli
  • Salvatore Panico
  • J. Ramon Quiros
  • Olov Rolandsson
  • Carlotta Sacerdote
  • Maria-Jose Sanchez
  • Nadia Slimani
  • Birgit Teucher
  • Anne Tjonneland
  • Rosario Tumino
  • Daphne L. van der A
  • Edith J. M. Feskens
  • Claudia Langenberg
  • Nita G. Forouhi
  • Elio Riboli
  • Nicholas J. Wareham
Publishing year: 2013
Language: English
Pages: 1012-1019
Publication/Series: Diabetes Care
Volume: 36
Issue: 4
Document type: Journal article
Publisher: American Diabetes Association

Abstract english

OBJECTIVE-Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk. RESEARCH DESIGN AND METHODS-Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied. RESULTS-Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04-1.69), 1.09 (0.90-1.31), 0.97 (0.86-1.10), and 0.85 (0.70-1.03) for women with menopause at ages <40, 40-44, 45-49, and >= 55 years, respectively, relative to those with menopause at age 50-54 years. The HR per SD younger age at menopause was 1.08 (1.02-1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [ 1.01-1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all > 0.05). CONCLUSIONS-Early menopause is associated with a greater risk of type 2 diabetes. Diabetes Care 36:1012-1019, 2013

Keywords

  • Endocrinology and Diabetes

Other

Published
  • Diabetes and Endocrinology
  • Internal Medicine
  • ISSN: 1935-5548
Paul Franks
E-mail: paul.franks [at] med.lu.se

Principal investigator

Genetic and Molecular Epidemiology

+46 40 39 11 49

60-12-021

33

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