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Tea Consumption and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study

Author:
  • Geertruida J. van Woudenbergh
  • Anneleen Kuijsten
  • Dagmar Drogan
  • Daphne L. van der A
  • Dora Romaguera
  • Eva Ardanaz
  • Pilar Amiano
  • Aurelio Barricarte
  • Joline W. J. Beulens
  • Heiner Boeing
  • H. Bas Bueno-de-Mesquita
  • Christina C. Dahm
  • M-Doleres Chirlaque
  • Fran-coise Clavel
  • Francesca L. Crowe
  • Piia-Piret Eomois
  • Guy Fagher-azzi
  • Paul Franks
  • Jytte Halkjaer
  • Kay T. Khaw
  • Giovanna Masala
  • Amalia Mattiello
  • Peter Nilsson
  • Kim Overvad
  • J. Ramon Quiros
  • Olov Rolandsson
  • Isabelle Romieu
  • Carlotta Sacerdote
  • Maria-Jose Sanchez
  • Matthias B. Schulze
  • Nadia Slimani
  • Ivonne Sluijs
  • Annemieke M. W. Spijkerman
  • Giovanna Tagliabue
  • Birgit Teucher
  • Anne Tjonneland
  • Rosario Tumino
  • Nita G. Forouhi
  • Stephen Sharp
  • Claudia Langenberg
  • Edith J. M. Feskens
  • Elio Riboli
  • Nicholas J. Wareham
Publishing year: 2012
Language: English
Publication/Series: PLoS ONE
Volume: 7
Issue: 5
Document type: Journal article
Publisher: Public Library of Science

Abstract english

Background: In previous meta-analyses, tea consumption has been associated with lower incidence of type 2 diabetes. It is unclear, however, if tea is associated inversely over the entire range of intake. Therefore, we investigated the association between tea consumption and incidence of type 2 diabetes in a European population. Methodology/Principal Findings: The EPIC-InterAct case-cohort study was conducted in 26 centers in 8 European countries and consists of a total of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,835 individuals from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Country-specific Hazard Ratios (HR) for incidence of type 2 diabetes were obtained after adjustment for lifestyle and dietary factors using a Cox regression adapted for a case-cohort design. Subsequently, country-specific HR were combined using a random effects meta-analysis. Tea consumption was studied as categorical variable (0, >0-<1, 1-<4, >= 4 cups/day). The dose-response of the association was further explored by restricted cubic spline regression. Country specific medians of tea consumption ranged from 0 cups/day in Spain to 4 cups/day in United Kingdom. Tea consumption was associated inversely with incidence of type 2 diabetes; the HR was 0.84 [95% CI 0.71, 1.00] when participants who drank >= 4 cups of tea per day were compared with non-drinkers (p(linear) (trend) = 0.04). Incidence of type 2 diabetes already tended to be lower with tea consumption of 1-<4 cups/day (HR = 0.93 [95% CI 0.81, 1.05]). Spline regression did not suggest a non-linear association (p(non-linearity) = 0.20). Conclusions/Significance: A linear inverse association was observed between tea consumption and incidence of type 2 diabetes. People who drink at least 4 cups of tea per day may have a 16% lower risk of developing type 2 diabetes than non-tea drinkers.

Keywords

  • Endocrinology and Diabetes

Other

Published
  • Genetic and Molecular Epidemiology
  • ISSN: 1932-6203
Paul Franks
E-mail: paul.franks [at] med.lu.se

Principal investigator

Genetic and Molecular Epidemiology

+46 40 39 11 49

60-12-021

33

Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00