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Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant A 14-Cohort Meta-analysis

Author:
  • Stavroula Kanoni
  • Jennifer A. Nettleton
  • Marie-France Hivert
  • Zheng Ye
  • Frank J. A. van Rooij
  • Dmitry Shungin
  • Emily Sonestedt
  • Julius S. Ngwa
  • Mary K. Wojczynski
  • Rozenn N. Lemaitre
  • Stefan Gustafsson
  • Jennifer S. Anderson
  • Toshiko Tanaka
  • George Hindy
  • Georgia Saylor
  • Frida Renstrom
  • Amanda J. Bennett
  • Cornelia M. van Duijn
  • Jose C. Florez
  • Caroline S. Fox
  • Albert Hofman
  • Ron C. Hoogeveen
  • Denise K. Houston
  • Frank B. Hu
  • Paul F. Jacques
  • Ingegerd Johansson
  • Lars Lind
  • Yongmei Liu
  • Nicola McKeown
  • Jose Ordovas
  • James S. Pankow
  • Eric J. G. Sijbrands
  • Ann-Christine Syvanen
  • Andre G. Uitterlinden
  • Mary Yannakoulia
  • M. Carola Zillikens
  • Nick J. Wareham
  • Inga Prokopenko
  • Stefania Bandinelli
  • Nita G. Forouhi
  • L. Adrienne Cupples
  • Ruth J. Loos
  • Goran Hallmans
  • Josee Dupuis
  • Claudia Langenberg
  • Luigi Ferrucci
  • Stephen B. Kritchevsky
  • Mark I. McCarthy
  • Erik Ingelsson
  • Ingrid B. Borecki
  • Jacqueline C. M. Witteman
  • Marju Orho-Melander
  • David S. Siscovick
  • James B. Meigs
  • Paul Franks
  • George V. Dedoussis
Publishing year: 2011
Language: English
Pages: 2407-2416
Publication/Series: Diabetes
Volume: 60
Issue: 9
Document type: Journal article
Publisher: American Diabetes Association

Abstract english

OBJECTIVE-Many genetic variants have been associated with glucose homeostasis and type 2 diabetes in genome-wide association studies. Zinc is an essential micronutrient that is important for beta-cell function and glucose homeostasis. We tested the hypothesis that zinc intake could influence the glucose-raising effect of specific variants. RESEARCH DESIGN AND METHODS-We conducted a 14-cohort meta-analysis to assess the interaction of 20 genetic variants known to be related to glycemic traits and zinc metabolism with dietary zinc intake (food sources) and a 5-cohort meta-analysis to assess the interaction with total zinc intake (food sources and supplements) on fasting glucose levels among individuals of European ancestry without diabetes. RESULTS-We observed a significant association of total zinc intake with lower fasting glucose levels (beta-coefficient +/- SE per 1 mg/day of zinc intake: -0.0012 +/- 0.0003 mmol/L, summary P value = 0.0003), while the association of dietary zinc intake was not significant. We identified a nominally significant interaction between total zinc intake and the SLC30A8 rs11558471 variant on fasting glucose levels (beta-coefficient +/- SE per A allele for 1 mg/day of greater total zinc intake: -0.0017 +/- 0.0006 mmol/L, summary interaction P value = 0.005); this result suggests a stronger inverse association between total zinc intake and fasting glucose in individuals carrying the glucose-raising A allele compared with individuals who do not carry it. None of the other interaction tests were statistically significant. CONCLUSIONS Our results suggest that higher total zinc intake may attenuate the glucose-raising effect of the rs11558471 SLC30A8 (zinc transporter) variant. Our findings also support evidence for the association of higher total zinc intake with lower fasting glucose levels. Diabetes 60:2407-2416, 2011

Keywords

  • Endocrinology and Diabetes

Other

Published
  • Genetic and Molecular Epidemiology
  • Diabetes and cardiovascular disease - genetic epidemiolgy
  • ISSN: 1939-327X
Paul Franks
E-mail: paul.franks [at] med.lu.se

Principal investigator

Genetic and Molecular Epidemiology

+46 40 39 11 49

60-12-021

33

Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00