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Gene-Lifestyle and Gene-Pharmacotherpy Interactions in Obesity and Its Cardiovascular Consequences.

Author:
  • Paul Franks
  • Alaitz Poveda
Publishing year: 2011
Language: English
Pages: 401-456
Publication/Series: Current Vascular Pharmacology
Volume: 9
Issue: 4
Document type: Journal article
Publisher: Bentham Science Publishers

Abstract english

Obesity is a highly prevalent complex trait that raises the risk of other chronic diseases such as type 2 diabetes, certain cancers, sleep apnea, and cardiovascular disease, and shortens lifespan. Clinical intervention studies focused on weight loss and epidemiological studies of obesity indicate that genetic variation may modify the relationship between lifestyle behaviors and weight loss or weight gain. Similar observations have also emerged from pharmacogenetic studies. The literature includes several reports from these studies, but few examples of interactions have been adequately replicated. In this review we introduce the topics of population genetics research and gene x environment interaction. We also provide a systematic review of the published literature on gene x lifestyle (physical activity and dietary factors) and gene x drug interactions in relation to obesity. Finally, we overview the scope and findings from these studies and discuss some of their strengths and limitations.

Keywords

  • Cardiac and Cardiovascular Systems
  • gene x drug interaction
  • Genetic
  • gene x lifestyle interaction
  • nutrition
  • nutriogenomics
  • obesity
  • pharmacogenetics
  • physical activity

Other

Published
  • Diabetes and Endocrinology
  • ISSN: 1570-1611
Paul Franks
E-mail: paul.franks [at] med.lu.se

Principal investigator

Genetic and Molecular Epidemiology

+46 40 39 11 49

60-12-021

33

Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00