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Common variants associated with plasma triglycerides and risk for coronary artery disease

Author:
  • Ron Do
  • Cristen J. Willer
  • Ellen M. Schmidt
  • Sebanti Sengupta
  • Chi Gao
  • Gina M. Peloso
  • Stefan Gustafsson
  • Stavroula Kanoni
  • Andrea Ganna
  • Jin Chen
  • Martin L. Buchkovich
  • Samia Mora
  • Jacques S. Beckmann
  • Jennifer L. Bragg-Gresham
  • Hsing-Yi Chang
  • Ayse Demirkan
  • Heleen M. Den Hertog
  • Louise A. Donnelly
  • Georg B. Ehret
  • Tonu Esko
  • Mary F. Feitosa
  • Teresa Ferreira
  • Krista Fischer
  • Pierre Fontanillas
  • Ross M. Fraser
  • Daniel F. Freitag
  • Deepti Gurdasani
  • Kauko Heikkila
  • Elina Hyppoenen
  • Aaron Isaacs
  • Anne U. Jackson
  • Asa Johansson
  • Toby Johnson
  • Marika Kaakinen
  • Johannes Kettunen
  • Marcus E. Kleber
  • Xiaohui Li
  • Jian'an Luan
  • Leo-Pekka Lyytikainen
  • Patrik K. E. Magnusson
  • Massimo Mangino
  • Evelin Mihailov
  • May E. Montasser
  • Martina Mueller-Nurasyid
  • Ilja M. Nolte
  • Jeffrey R. O'Connell
  • Cameron D. Palmer
  • Markus Perola
  • Ann-Kristin Petersen
  • Serena Sanna
  • Richa Saxena
  • Susan K. Service
  • Sonia Shah
  • Dmitry Shungin
  • Carlo Sidore
  • Ci Song
  • Rona J. Strawbridge
  • Ida Surakka
  • Toshiko Tanaka
  • Tanya M. Teslovich
  • Gudmar Thorleifsson
  • Evita G. Van den Herik
  • Benjamin F. Voight
  • Kelly A. Volcik
  • Lindsay L. Waite
  • Andrew Wong
  • Ying Wu
  • Weihua Zhang
  • Devin Absher
  • Gershim Asiki
  • Ines Barroso
  • Latonya F. Been
  • Jennifer L. Bolton
  • Lori L. Bonnycastle
  • Paolo Brambilla
  • Mary S. Burnett
  • Giancarlo Cesana
  • Maria Dimitriou
  • Alex S. F. Doney
  • Angela Doering
  • Paul Elliott
  • Stephen E. Epstein
  • Gudmundur Ingi Eyjolfsson
  • Bruna Gigante
  • Mark O. Goodarzi
  • Harald Grallert
  • Martha L. Gravito
  • Christopher J. Groves
  • Goran Hallmans
  • Anna-Liisa Hartikainen
  • Caroline Hayward
  • Dena Hernandez
  • Andrew A. Hicks
  • Hilma Holm
  • Yi-Jen Hung
  • Thomas Illig
  • Michelle R. Jones
  • Pontiano Kaleebu
  • John J. P. Kastelein
  • Kay-Tee Khaw
  • Eric Kim
  • Norman Klopp
  • Pirjo Komulainen
  • Meena Kumari
  • Claudia Langenberg
  • Terho Lehtimaki
  • Shih-Yi Lin
  • Jaana Lindstrom
  • Ruth J. F. Loos
  • Francois Mach
  • Wendy L. McArdle
  • Christa Meisinger
  • Braxton D. Mitchell
  • Gabrielle Mueller
  • Ramaiah Nagaraja
  • Narisu Narisu
  • Tuomo V. M. Nieminen
  • Rebecca N. Nsubuga
  • Isleifur Olafsson
  • Ken K. Ong
  • Aarno Palotie
  • Theodore Papamarkou
  • Cristina Pomilla
  • Anneli Pouta
  • Daniel J. Rader
  • Muredach P. Reilly
  • Paul M. Ridker
  • Fernando Rivadeneira
  • Igor Rudan
  • Aimo Ruokonen
  • Nilesh Samani
  • Hubert Scharnagl
  • Janet Seeley
  • Kaisa Silander
  • Alena Stancakova
  • Kathleen Stirrups
  • Amy J. Swift
  • Laurence Tiret
  • Andre G. Uitterlinden
  • L. Joost van Pelt
  • Sailaja Vedantam
  • Nicholas Wainwright
  • Cisca Wijmenga
  • Sarah H. Wild
  • Gonneke Willemsen
  • Tom Wilsgaard
  • James F. Wilson
  • Elizabeth H. Young
  • Jing Hua Zhao
  • Linda S. Adair
  • Dominique Arveiler
  • Themistocles L. Assimes
  • Stefania Bandinelli
  • Franklyn Bennett
  • Murielle Bochud
  • Bernhard O. Boehm
  • Dorret I. Boomsma
  • Ingrid B. Borecki
  • Stefan R. Bornstein
  • Pascal Bovet
  • Michel Burnier
  • Harry Campbell
  • Aravinda Chakravarti
  • John C. Chambers
  • Yii-Der Ida Chen
  • Francis S. Collins
  • Richard S. Cooper
  • John Danesh
  • George Dedoussis
  • Ulf de Faire
  • Alan B. Feranil
  • Jean Ferrieres
  • Luigi Ferrucci
  • Nelson B. Freimer
  • Christian Gieger
  • Leif Groop
  • Vilmundur Gudnason
  • Ulf Gyllensten
  • Anders Hamsten
  • Tamara B. Harris
  • Aroon Hingorani
  • Joel N. Hirschhorn
  • Albert Hofman
  • G. Kees Hovingh
  • Chao Agnes Hsiung
  • Steve E. Humphries
  • Steven C. Hunt
  • Kristian Hveem
  • Carlos Iribarren
  • Marjo-Riitta Jarvelin
  • Antti Jula
  • Mika Kahonen
  • Jaakko Kaprio
  • Antero Kesaniemi
  • Mika Kivimaki
  • Jaspal S. Kooner
  • Peter J. Koudstaal
  • Ronald M. Krauss
  • Diana Kuh
  • Johanna Kuusisto
  • Kirsten O. Kyvik
  • Markku Laakso
  • Timo A. Lakka
  • Lars Lind
  • Cecilia M. Lindgren
  • Nicholas G. Martin
  • Winfried Maerz
  • Mark I. McCarthy
  • Colin A. McKenzie
  • Pierre Meneton
  • Andres Metspalu
  • Leena Moilanen
  • Andrew D. Morris
  • Patricia B. Munroe
  • Inger Njolstad
  • Nancy L. Pedersen
  • Chris Power
  • Peter P. Pramstaller
  • Jackie F. Price
  • Bruce M. Psaty
  • Thomas Quertermous
  • Rainer Rauramaa
  • Danish Saleheen
  • Veikko Salomaa
  • Dharambir K. Sanghera
  • Jouko Saramies
  • Peter E. H. Schwarz
  • Wayne H-H Sheu
  • Alan R. Shuldiner
  • Agneta Siegbahn
  • Tim D. Spector
  • Kari Stefansson
  • David P. Strachan
  • Bamidele O. Tayo
  • Elena Tremoli
  • Jaakko Tuomilehto
  • Matti Uusitupa
  • Cornelia M. van Duijn
  • Peter Vollenweider
  • Lars Wallentin
  • Nicholas J. Wareham
  • John B. Whitfield
  • Bruce H. R. Wolffenbuttel
  • David Altshuler
  • Jose M. Ordovas
  • Eric Boerwinkle
  • Colin N. A. Palmer
  • Unnur Thorsteinsdottir
  • Daniel I. Chasman
  • Jerome I. Rotter
  • Paul Franks
  • Samuli Ripatti
  • L. Adrienne Cupples
  • Manjinder S. Sandhu
  • Stephen S. Rich
  • Michael Boehnke
  • Panos Deloukas
  • Karen L. Mohlke
  • Erik Ingelsson
  • Goncalo R. Abecasis
  • Mark J. Daly
  • Benjamin M. Neale
  • Sekar Kathiresan
Publishing year: 2013
Language: English
Pages: 1345-1345
Publication/Series: Nature Genetics
Volume: 45
Issue: 11
Document type: Journal article
Publisher: Nature Publishing Group

Abstract english

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 x 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.

Keywords

  • Endocrinology and Diabetes

Other

Published
  • Diabetes and Endocrinology
  • Genetic and Molecular Epidemiology
  • ISSN: 1546-1718
Paul Franks
E-mail: paul.franks [at] med.lu.se

Principal investigator

Genetic and Molecular Epidemiology

+46 40 39 11 49

60-12-021

33

Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00