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Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study.

Author:
  • Frida Renström
  • Robert Koivula
  • Tibor V Varga
  • Göran Hallmans
  • Hindrik Mulder
  • Jose C Florez
  • Frank B Hu
  • Paul Franks
Publishing year: 2015
Language: English
Pages: 997-1005
Publication/Series: Diabetologia
Volume: 58
Issue: 5
Document type: Journal article
Publisher: Springer Verlag

Abstract english

The association of single nucleotide polymorphisms (SNPs) proximal to CRY2 and MTNR1B with fasting glucose is well established. CRY1/2 and MTNR1B encode proteins that regulate circadian rhythmicity and influence energy metabolism. Here we tested whether season modified the relationship of these loci with blood glucose concentration.

Keywords

  • Endocrinology and Diabetes

Other

Published
  • Genetic and Molecular Epidemiology
  • Molecular Metabolism
  • ISSN: 1432-0428
Paul Franks
E-mail: paul.franks [at] med.lu.se

Principal investigator

Genetic and Molecular Epidemiology

+46 40 39 11 49

60-12-021

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Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00