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Ceruloplasmin and atrial fibrillation: evidence of causality from a population-based Mendelian randomization study.

Author:
  • Samuel Adamsson Eryd
  • Marketa Sjögren
  • Gustav Smith
  • Peter Nilsson
  • Olle Melander
  • Bo Hedblad
  • Gunnar Engström
Publishing year: 2014
Language: English
Pages: 164-171
Publication/Series: Journal of Internal Medicine
Volume: 275
Issue: 2
Document type: Journal article
Publisher: Wiley-Blackwell

Abstract english

Inflammatory diseases and inflammatory markers secreted by the liver, including C-reactive protein (CRP) and ceruloplasmin, have been associated with incident atrial fibrillation (AF). Genetic studies have not supported a causal relationship between CRP and AF, but the relationship between ceruloplasmin and AF has not been studied. The purpose of this Mendelian randomization study was to explore whether genetic polymorphisms in the gene encoding ceruloplasmin are associated with elevated ceruloplasmin levels, and whether such genetic polymorphisms are also associated with the incidence of AF.

Keywords

  • Cardiac and Cardiovascular Systems

Other

Published
  • Cardio-vascular Epidemiology
  • Hypertension and Cardiovascular Disease
  • Internal Medicine
  • ISSN: 1365-2796
E-mail: gustav.smith [at] med.lu.se

Associate professor

Cardiology

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Research project participant

Cardiovascular Epigenetics

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Research project participant

Heart Failure and Mechanical Support

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Project manager

Molecular Epidemiology and Cardiology

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