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Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.

Author:
  • Gustav Smith
  • Kevin Luk
  • Christina-Alexandra Schulz
  • James C Engert
  • Ron Do
  • George Hindy
  • Gull Rukh
  • Line Dufresne
  • Peter Almgren
  • David S Owens
  • Tamara B Harris
  • Gina M Peloso
  • Kathleen F Kerr
  • Quenna Wong
  • Albert V Smith
  • Matthew J Budoff
  • Jerome I Rotter
  • L Adrienne Cupples
  • Stephen Rich
  • Sekar Kathiresan
  • Marju Orho-Melander
  • Vilmundur Gudnason
  • Christopher J O'Donnell
  • Wendy S Post
  • George Thanassoulis
Publishing year: 2014
Language: English
Pages: 1764-1771
Publication/Series: JAMA: the journal of the American Medical Association
Volume: 312
Issue: 17
Document type: Journal article
Publisher: American Medical Association

Abstract english

Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.

Keywords

  • Endocrinology and Diabetes

Other

Published
  • Diabetes and cardiovascular disease - genetic epidemiolgy
  • Diabetes and Endocrinology
  • ISSN: 1538-3598
E-mail: gustav.smith [at] med.lu.se

Associate professor

Cardiology

+46 46 17 26 33

D1232C

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Research project participant

Cardiovascular Epigenetics

32

Research project participant

Heart Failure and Mechanical Support

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Project manager

Molecular Epidemiology and Cardiology

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Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00