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Psychological manifestations of celiac disease autoimmunity in young children

Author:
  • Laura B. Smith
  • Kristian Lynch
  • Kalle Kurppa
  • Sibylle Koletzko
  • Jeffrey Krischer
  • Edwin Liu
  • Suzanne Bennett Johnson
  • Daniel Agardh
  • Marian Rewers
  • Kimberly Bautista
  • Judith Baxter
  • Ruth Bedoy
  • Daniel Felipe-Morales
  • Brigitte I. Frohnert
  • Patricia Gesualdo
  • Michelle Hoffman
  • Rachel Karban
  • Jill Norris
  • Adela Samper-Imaz
  • Andrea K Steck
  • Kathleen Waugh
  • Hali Wright
  • Jin-Xiong She
  • Desmond Schatz
  • Diane Hopkins
  • Leigh Steed
  • Jamie Thomas
  • Janey Adams
  • Katherine Silvis
  • Michael J. Haller
  • Melissa Gardiner
  • Richard McIndoe
  • Ashok Sharma
  • Joshua W Williams
  • Gabriela Young
  • S Anderson
  • Laura Mary Jacobsen
  • Anette-G Ziegler
  • Andreas Beyerlein
  • Ezio Bonifacio
  • Michael Hummel
  • Sandra Hummel
  • Kristina Foterek
  • Nicole Janz
  • Mathilde Kersting
  • Annette Knopff
  • Claudia Peplow
  • Roswith Roth
  • Marlon Scholz
  • Joanna Stock
  • Elisabeth Strauss
  • Katharina Warncke
  • Lorena Wendel
  • Christiane Winkler
  • Jorma Toppari
  • Olli G. Simell
  • Annika Adamsson
  • Suvi Ahonen
  • Heikki Hyöty
  • Jorma Ilonen
  • Sanna Jokipuu
  • Tiina Kallio
  • Leena Karlsson
  • Miia Kähönen
  • Mikael Knip
  • Lea Kovanen
  • Mirva Koreasalo
  • Tiina Latva-Aho
  • Maria Lönnrot
  • Elina Mäntymäki
  • Katja Multasuo
  • Juha Mykkänen
  • Tiina Niininen
  • Sari Niinistö
  • Mia Nyblom
  • Petra Rajala
  • Jenna Rautanen
  • Anne Riikonen
  • Mika Riikonen
  • Jenni Rouhiainen
  • Minna Romo
  • Tuula Simell
  • Ville Simell
  • Maija Sjöberg
  • Aino Stenius
  • Maria Leppänen
  • Sini Vainionpää
  • Eeva Varjonen
  • Riitta Veijola
  • Suvi M Virtanen
  • Mari Vähä-Mäkilä
  • Mari Åkerlund
  • Katri Lindfors
  • Åke Lernmark
  • Carin Andrén Aronsson
  • Maria Ask
  • Jenny Bremer
  • Ulla Marie Carlsson
  • Corrado Cilio
  • Emelie Ericson-Hallström
  • Lina Fransson
  • Thomas Gard
  • Joanna Gerardsson
  • Rasmus Bennet
  • Monica Hansen
  • Gertie Hansson
  • Cecilia Harmby
  • Suzanne Hyberg-Karlsson
  • Fredrik Johansen
  • Berglind Jonsdottir
  • Helena Elding Larsson
  • Sigrid Lenrick Forss
  • Markus Lundgren
  • Maria Månsson-Martinez
  • Maria Markan
  • Marie Jessica Melin
  • Zeliha Mestan
  • Kobra Rahmati
  • Anita Ramelius
  • Anna Rosenquist
  • Falastin Salami
  • Sara Sibthorpe
  • Birgitta Sjöberg
  • Ulrica Swartling
  • Evelyn Tekum Amboh
  • Carina Törn
  • Anne Wallin
  • Åsa Wimar
  • Sofie Åberg
  • William A. Hagopian
  • Michael Killian
  • Claire Cowen Crouch
  • Jennifer Skidmore
  • Josephine Carson
  • Kayleen Dunson
  • Rachel Hervey
  • Corbin Johnson
  • Rachel Lyons
  • Arlene Meyer
  • Denise Mulenga
  • Allison Schwartz
  • Joshua Stabbert
  • Alexander Tarr
  • Morgan Uland
  • John Willis
  • Dorothy Becker
  • Margaret Franciscus
  • Mary Ellen Dalmagro Elias Smith
  • Ashi Daftary
  • Mary Beth Klein
  • Chrystal Yates
  • Jeffrey P Krischer
  • Michael Abbondondolo
  • Sarah Austin-Gonzalez
  • Maryouri Avendano
  • Sandra Baethke
  • Rasheedah Brown
  • Brant R. Burkhardt
  • Martha Butterworth
  • Joanna Clasen
  • David Cuthbertson
  • Christopher Eberhard
  • Steven W. Fiske
  • Dena Garcia
  • Jennifer Garmeson
  • Veena Gowda
  • Kathleen Heyman
  • Francisco Perez Laras
  • Hye-Seung Lee
  • Shu Liu
  • Xiang Liu
  • Kristian Lynch
  • Jamie Malloy
  • Cristina McCarthy
  • Steven Meulemans
  • Hemang Parikh
  • Chris Shaffer
  • Laura Smith
  • Susan Smith
  • Noah Sulman
  • Roy N. Tamura
  • Ulla Uusitalo
  • Kendra Vehik
  • Ponni Vijayakandipan
  • Keith Wood
  • Jimin Yang
  • Lori Ballard
  • David Hadley
  • Wendy Mcleod
  • Beena Akolkar
  • Henry Erlich
  • Steven J. Mack
  • Anna Lisa Fear
  • Sandra Ke
  • Niveen Mulholland
  • Kasia Bourcier
  • Thomas Briese
  • Eric W Triplett
Publishing year: 2017-03-01
Language: English
Publication/Series: Pediatrics
Volume: 139
Issue: 3
Document type: Journal article
Publisher: American Academy of Pediatrics

Abstract english

BACKGROUND AND OBJECTIVES: Psychological symptoms can be associated with celiac disease; abstract however, this association has not been studied prospectively in a pediatric cohort. We examined mother report of psychological functioning in children persistently positive for tissue transglutaminase autoantibodies (tTGA), defined as celiac disease autoimmunity (CDA), compared with children without CDA in a screening population of genetically at-risk children. We also investigated differences in psychological symptoms based on mothers' awareness of their child's CDA status. METHODS: The Environmental Determinants of Diabetes in the Young study followed 8676 children to identify triggers of type 1 diabetes and celiac disease. Children were tested for tTGA beginning at 2 years of age. The Achenbach Child Behavior Checklist assessed child psychological functioning at 3.5 and 4.5 years of age. RESULTS: At 3.5 years, 66 mothers unaware their child had CDA reported more child anxiety and depression, aggressive behavior, and sleep problems than 3651 mothers of children without CDA (all Ps ≤ .03). Unaware-CDA mothers also reported more child anxiety and depression, withdrawn behavior, aggressive behavior, and sleep problems than 440 mothers aware of their child's CDA status (all Ps ≤.04). At 4.5 years, there were no differences. CONCLUSIONS: In 3.5-year-old children, CDA is associated with increased reports of child depression and anxiety, aggressive behavior, and sleep problems when mothers are unaware of their child's CDA status. Mothers' knowledge of their child's CDA status is associated with fewer reports of psychological symptoms, suggesting that awareness of the child's tTGA test results affects reporting of symptoms.

Keywords

  • Pediatrics
  • celiac disease
  • yong children
  • psychological

Other

Published
  • Diabetes and Celiac Unit
  • Cellular Autoimmunity
  • Paediatric Endocrinology
  • Neonatology
  • ISSN: 0031-4005
E-mail: falastin.salami [at] med.lu.se

Research project participant

Diabetes and Celiac Unit

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