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From PDE3B to the regulation of energy homeostasis.

Author:
  • Eva Degerman
  • Faiyaz Ahmad
  • Youn Wook Chung
  • Emilia Guirguis
  • Bilal Omar
  • Lena Stenson
  • Vincent Manganiello
Publishing year: 2011
Language: English
Pages: 676-682
Publication/Series: Current Opinion in Pharmacology
Volume: 11
Document type: Journal article
Publisher: Elsevier

Abstract english

The incidence of obesity in the developed world is increasing at an alarming rate. Concurrent with the increase in the incidence of obesity is an increase in the incidence of type 2 diabetes. Cyclic AMP (cAMP) and cGMP are key second messengers in all cells; for example, when it comes to processes of relevance for the regulation of energy metabolism, cAMP is a key mediator in the regulation of lipolysis, glycogenolysis, gluconeogenesis and pancreatic β cell insulin secretion. PDE3B, one of several enzymes which hydrolyze cAMP and cGMP, is expressed in cells of importance for the regulation of energy homeostasis, including adipocytes, hepatocytes, hypothalamic cells and β cells. It has been shown, using PDE3 inhibitors and gene targeting approaches in cells and animals, that altered levels of PDE3B result in a number of changes in the regulation of glucose and lipid metabolism and in overall energy homeostasis. This article highlights the complexity involved in the regulation of PDE3B by hormones, and in the regulation of downstream metabolic effects by PDE3B in several interacting tissues.

Keywords

  • Endocrinology and Diabetes

Other

Published
  • Insulin Signal Transduction
  • ISSN: 1471-4973
Eva Degerman
E-mail: eva.degerman [at] med.lu.se

Professor

Insulin Signal Transduction

+46 46 222 85 83

+46 70 885 83 62

BMC C1121b

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Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00