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Novel supermacroporous dextran gels

Author:
  • Fatima Plieva
  • Alina Oknianska
  • Eva Degerman
  • Igor Galaev
  • Bo Mattiasson
Publishing year: 2006
Language: English
Pages: 1075-1092
Publication/Series: Journal of Biomaterials Science. Polymer Edition
Volume: 17
Issue: 10
Document type: Journal article
Publisher: VSP BV

Abstract english

Supermacroporous dextran gels (SDGs), having pores tens of micrometers in size and highly interconnected, were prepared from dextran macromonomer through radical polymerization at subzero temperatures and compared with dextran gels prepared at ambient temperature. Dextran macromonomer was synthesized via glycidyl methacrylate derivatization of dextran T500 in DMSO medium. The derivatization of dextran was confirmed by H-1-NMR and FT-IR spectroscopy. Scanning electron microscopy revealed macropores up to 100 mu m in size. SDGs can be dried and re-swollen within seconds retaining their porous structure. The large size of interconnected pores, fast swelling and biocompatibility of dextran make SDGs promising material for tissue engineering and cell culture.

Keywords

  • Basic Medicine
  • cell
  • interconnected pores
  • swelling
  • dextran
  • supermacroporous gel
  • scaffolds

Other

Published
  • Insulin Signal Transduction
  • ISSN: 0920-5063
Eva Degerman
E-mail: eva.degerman [at] med.lu.se

Professor

Insulin Signal Transduction

+46 46 222 85 83

+46 70 885 83 62

BMC C1121b

66

Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00