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PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells

Author:
  • Lena Eliasson
  • Erik Renström
  • Carina Ammala
  • Per-Olof Berggren
  • Alejandro M. Bertorello
  • Krister Bokvist
  • Alexander Chibalin
  • Jude T. Deeney
  • Peter R. Flatt
  • Jakob Gabel
  • Jesper Gromada
  • Olof Larsson
  • Per Lindstrom
  • Christopher J. Rhodes
  • Patrik Rorsman
Publishing year: 1996
Language: English
Pages: 813-815
Publication/Series: Science
Volume: 271
Issue: 5250
Document type: Journal article
Publisher: The American Association for the Advancement of Science

Abstract english

Hypoglycemic sulfonylureas represent a group of clinically useful antidiabetic compounds that stimulate insulin secretion from pancreatic beta cells. The molecular mechanisms involved are not fully understood but are believed to involve inhibition of potassium channels sensitive to adenosine triphosphate (KATP channels) in the beta cell membrane, causing membrane depolarization, calcium influx, and activation of the secretory machinery. In addition to these effects, sulfonylureas also promoted exocytosis by direct interaction with the secretory machinery not involving closure of the plasma membrane KATP channels. This effect was dependent on protein kinase C (PKC) and was observed at therapeutic concentrations of sulfonylureas, which suggests that it contributes to their hypoglycemic action in diabetics.

Keywords

  • Endocrinology and Diabetes

Other

Published
  • Islet patophysiology
  • ISSN: 1095-9203
Erik Renström
E-mail: erik.renstrom [at] med.lu.se

Deputy head of department

Department of Clinical Sciences, Malmö

+46 40 39 11 57

+46 40 39 11 57

Principal investigator

Islet patophysiology

+46 40 39 11 57

+46 40 39 11 57

20-3-308

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Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00